rectal disease: A disease that involves the rectum. [database_cross_reference: MONDO:patterns/location]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
12814 |
4. Check minimum number of eventsNone |
12814 |
5. Include endpointsNone |
12814 |
6. Filter based on genotype QC (FinnGen only) |
12339 |
Control definitions (FinnGen only)
Control exclude
K11_INTESTOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K55-K63
Name in latin
Alii morbi ani et recti
Other diseases of anus and rectum
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 104510 | 58332 | 45441 |
| Only index persons | 90795 | 51505 | 39290 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.49 | 1.67 | 1.27 |
| Only index persons | 1.72 | 1.89 | 1.50 |
| Median age at first event (years) | |||
| Whole population | 62.86 | 64.48 | 60.73 |
| Only index persons | 61.46 | 62.87 | 59.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 12339 | 6753 | 5586 |
| Unadjusted period prevalence (%) | 2.72 | 2.65 | 2.81 |
| Median age at first event (years) | 61.00 | 58.03 | 64.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_OTHANRECT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OTHANRECT | 1.483 [1.36, 1.62] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.159 |
During the follow-up period (1.1.1998 — 31.12.2019), 13064 out of 45745 females with K11_OTHANRECT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_OTHANRECT | 1.492 [1.36, 1.64] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 10602 out of 35708 males with K11_OTHANRECT died.
Mortality risk
Mortality risk for people of age
years, who have K11_OTHANRECT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.151% | 0.238% |
| 5 | 0.876% | 1.744% |
| 10 | 2.137% | 4.233% |
| 15 | 4.04% | 7.725% |
| 20 | 7.059% | 13.225% |
Relationships between endpoints
↥Index endpoint: K11_OTHANRECT – Other diseases of anus and rectum
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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