otitis externa: Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
13184 |
4. Check minimum number of eventsNone |
13184 |
5. Include endpoints |
13979 |
6. Filter based on genotype QC (FinnGen only) |
13398 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Diseases of external ear
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 123000 | 60414 | 61926 |
| Only index persons | 109849 | 54836 | 55013 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.72 | 1.73 | 1.73 |
| Only index persons | 2.06 | 2.02 | 2.10 |
| Median age at first event (years) | |||
| Whole population | 47.12 | 47.11 | 47.19 |
| Only index persons | 48.65 | 48.68 | 48.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 13398 | 7056 | 6342 |
| Unadjusted period prevalence (%) | 2.97 | 2.77 | 3.19 |
| Median age at first event (years) | 56.06 | 52.55 | 59.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_EXTERNAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXTERNAL | 1.314 [1.18, 1.46] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.102 |
During the follow-up period (1.1.1998 — 31.12.2019), 5547 out of 43185 females with H8_EXTERNAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXTERNAL | 1.251 [1.13, 1.39] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 6779 out of 43579 males with H8_EXTERNAL died.
Mortality risk
Mortality risk for people of age
years, who have H8_EXTERNAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.232% |
| 5 | 0.65% | 1.49% |
| 10 | 1.658% | 3.616% |
| 15 | 3.229% | 6.689% |
| 20 | 5.868% | 11.254% |
Relationships between endpoints
↥Index endpoint: H8_EXTERNAL – Diseases of external ear
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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