≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Impacted cerumen

DOID EFO Endpoint Browser PheWeb

H8_CERUMEN

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H61.2
  • Hospital discharge: ICD-9 — 3804
  • Hospital discharge: ICD-8 — 38710
  • Cause of death: ICD-10 — H61.2
  • Cause of death: ICD-9 — 3804
  • Cause of death: ICD-8 — 38710

2 out of 7 registries used, show all original rules.

3302

4. Check minimum number of events

None

3302

5. Include endpoints

None

3302

6. Filter based on genotype QC (FinnGen only)

3167

Control definitions (FinnGen only)

Control exclude H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H61
Name in latin Cerumen obturans

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 28534 13931 14491
Only index persons 24697 12195 12502
Unadjusted period prevalence (%)
Whole population 0.40 0.40 0.40
Only index persons 0.46 0.45 0.48
Median age at first event (years)
Whole population 60.28 63.18 57.60
Only index persons 63.70 66.23 61.23

-FinnGen-

Key figures

All Female Male
Number of individuals 3167 1548 1619
Unadjusted period prevalence (%) 0.71 0.61 0.81
Median age at first event (years) 68.73 66.99 70.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint H8_CERUMEN and mortality.

Females

Parameter HR [95% CI] p-value
H8_CERUMEN 1.112 [0.97, 1.27] 0.114
Birth year 0.996 [0.99, 1.0] 0.302

During the follow-up period (1.1.1998 — 31.12.2019), 1825 out of 8627 females with H8_CERUMEN died.

Males

Parameter HR [95% CI] p-value
H8_CERUMEN 1.225 [1.06, 1.42] 0.006
Birth year 0.989 [0.98, 1.0] 0.02

During the follow-up period (1.1.1998 — 31.12.2019), 1919 out of 8943 males with H8_CERUMEN died.

Mortality risk

Mortality risk for people of age

years, who have H8_CERUMEN.

N-year risk Females Males
1 0.092% 0.232%
5 0.661% 1.536%
10 1.651% 3.767%
15 3.381% 7.112%
20 5.82% 11.886%

Relationships between endpoints

↥

Index endpoint: H8_CERUMEN – Impacted cerumen

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data