Disorder of external ear, unspecified

H8_EXTDISINOTH

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H62*
  • Cause of death: ICD-10 H62*

2 out of 7 registries used, show all original rules.

1023

4. Check minimum number of events

None

1023

5. Include endpoints

None

1023

6. Filter based on genotype QC (FinnGen only)

991

Control definitions (FinnGen only)

Control exclude H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7369 3573 3766
Only index persons 7023 3453 3570
Unadjusted period prevalence (%)
Whole population 0.10 0.10 0.11
Only index persons 0.13 0.13 0.14
Median age at first event (years)
Whole population 57.40 57.69 57.22
Only index persons 57.52 57.75 57.29

-FinnGen-

Key figures

All Female Male
Number of individuals 991 517 474
Unadjusted period prevalence (%) 0.22 0.20 0.24
Median age at first event (years) 58.72 56.65 60.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H8_EXTDISINOTH and mortality.

Females

Parameter HR [95% CI] p-value
H8_EXTDISINOTH 1.404 [1.19, 1.66] < 0.001
Birth year 0.998 [0.99, 1.01] 0.619

During the follow-up period (1.1.1998 — 31.12.2019), 419 out of 2954 females with H8_EXTDISINOTH died.

Males

Parameter HR [95% CI] p-value
H8_EXTDISINOTH 1.515 [1.27, 1.8] < 0.001
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 517 out of 3092 males with H8_EXTDISINOTH died.

Mortality risk

Mortality risk for people of age

years, who have H8_EXTDISINOTH.

N-year risk Females Males
1 0.167% 0.355%
5 0.973% 1.728%
10 2.414% 4.346%
15 4.32% 8.045%
20 7.788% 13.438%

Relationships between endpoints

Index endpoint: H8_EXTDISINOTH – Disorder of external ear, unspecified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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