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Perichondritis of external ear

DOID EFO Endpoint Browser PheWeb

H8_PERCHRONDR

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H61.0
  • Hospital discharge: ICD-9 — 3800
  • Hospital discharge: ICD-8 — 38798
  • Cause of death: ICD-10 — H61.0
  • Cause of death: ICD-9 — 3800
  • Cause of death: ICD-8 — 38798

2 out of 7 registries used, show all original rules.

548

4. Check minimum number of events

None

548

5. Include endpoints

None

548

6. Filter based on genotype QC (FinnGen only)

530

Control definitions (FinnGen only)

Control exclude H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H61
Name in latin Perichondritis auris externae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4952 2479 2432
Only index persons 4192 2180 2012
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.07
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 49.13 53.02 45.11
Only index persons 47.52 51.82 42.85

-FinnGen-

Key figures

All Female Male
Number of individuals 530 275 255
Unadjusted period prevalence (%) 0.12 0.11 0.13
Median age at first event (years) 46.12 46.73 45.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint H8_PERCHRONDR and mortality.

Females

Parameter HR [95% CI] p-value
H8_PERCHRONDR 1.613 [1.35, 1.93] < 0.001
Birth year 0.994 [0.99, 1.0] 0.2

During the follow-up period (1.1.1998 — 31.12.2019), 337 out of 1198 females with H8_PERCHRONDR died.

Males

Parameter HR [95% CI] p-value
H8_PERCHRONDR 1.223 [1.0, 1.49] 0.046
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 924 males with H8_PERCHRONDR died.

Mortality risk

Mortality risk for people of age

years, who have H8_PERCHRONDR.

N-year risk Females Males
1 0.155% 0.181%
5 1.027% 1.238%
10 2.192% 3.306%
15 4.13% 6.583%
20 7.925% 10.866%

Relationships between endpoints

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Index endpoint: H8_PERCHRONDR – Perichondritis of external ear

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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