auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
282 |
4. Check minimum number of eventsNone |
282 |
5. Include endpointsNone |
282 |
6. Filter based on genotype QC (FinnGen only) |
277 |
Control definitions (FinnGen only)
Control exclude
H8_EXTERNAL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H61
Name in latin
Stenosis meatus acustici externi acquisita
Similar endpoints
↥List of similar endpoints to
Acquired stenosis of external ear canal
based on the number of shared cases.
Similar with more cases:
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1833 | 644 | 1188 |
| Only index persons | 1756 | 613 | 1143 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.02 | 0.03 |
| Only index persons | 0.04 | 0.02 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 57.68 | 56.60 | 58.25 |
| Only index persons | 57.63 | 56.73 | 58.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 277 | 88 | 189 |
| Unadjusted period prevalence (%) | 0.08 | 0.03 | 0.09 |
| Median age at first event (years) | 59.63 | 54.20 | 62.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H8_STENOEXTCAN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_STENOEXTCAN | 1.036 [0.77, 1.39] | 0.814 |
| Birth year | 0.994 [0.99, 1.0] | 0.2 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 489 females with H8_STENOEXTCAN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_STENOEXTCAN | 1.014 [0.79, 1.31] | 0.914 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 868 males with H8_STENOEXTCAN died.
Mortality risk
Mortality risk for people of age
years, who have H8_STENOEXTCAN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.156% |
| 5 | 0.533% | 1.027% |
| 10 | 1.478% | 2.479% |
| 15 | 2.824% | 4.708% |
| 20 | 4.799% | 7.887% |
Relationships between endpoints
↥Index endpoint: H8_STENOEXTCAN – Acquired stenosis of external ear canal
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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