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Other otitis externa (chronic)

DOID EFO Endpoint Browser PheWeb

H8_EXT_OTH

otitis externa: Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H60.8
  • Hospital discharge: ICD-9 — 3801
  • Hospital discharge: excluded ICD-9 — 3801A|3801B|3801C
  • Cause of death: ICD-10 — H60.8
  • Cause of death: ICD-9 — 3801
  • Cause of death: excluded ICD-9 — 3801A|3801B|3801C

2 out of 7 registries used, show all original rules.

2248

4. Check minimum number of events

None

2248

5. Include endpoints

None

2248

6. Filter based on genotype QC (FinnGen only)

2141

Control definitions (FinnGen only)

Control exclude H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H60
Name in latin Alia otitis externa specificata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17524 9534 7906
Only index persons 16141 8961 7180
Unadjusted period prevalence (%)
Whole population 0.25 0.27 0.22
Only index persons 0.30 0.33 0.27
Median age at first event (years)
Whole population 50.96 50.37 51.78
Only index persons 51.17 50.52 51.97

-FinnGen-

Key figures

All Female Male
Number of individuals 2141 1256 885
Unadjusted period prevalence (%) 0.47 0.49 0.44
Median age at first event (years) 55.19 51.80 59.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H8_EXT_OTH and mortality.

Females

Parameter HR [95% CI] p-value
H8_EXT_OTH 1.082 [0.96, 1.22] 0.212
Birth year 0.997 [0.99, 1.01] 0.452

During the follow-up period (1.1.1998 — 31.12.2019), 895 out of 7630 females with H8_EXT_OTH died.

Males

Parameter HR [95% CI] p-value
H8_EXT_OTH 1.135 [1.01, 1.28] 0.035
Birth year 0.993 [0.98, 1.0] 0.119

During the follow-up period (1.1.1998 — 31.12.2019), 1100 out of 6157 males with H8_EXT_OTH died.

Mortality risk

Mortality risk for people of age

years, who have H8_EXT_OTH.

N-year risk Females Males
1 0.105% 0.268%
5 0.64% 1.405%
10 1.608% 3.864%
15 3.318% 7.644%
20 5.707% 12.63%

Relationships between endpoints

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Index endpoint: H8_EXT_OTH – Other otitis externa (chronic)

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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