Otitis externa

H8_EXTOTITIS

otitis externa: Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H60
  • Cause of death: ICD-10 H60

2 out of 7 registries used, show all original rules.

8368

4. Check minimum number of events

None

8368

5. Include endpoints

8846

6. Filter based on genotype QC (FinnGen only)

8455

Control definitions (FinnGen only)

Control exclude H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H60-H62
Name in latin Otitis externa

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 79705 40861 38381
Only index persons 71810 37481 34329
Unadjusted period prevalence (%)
Whole population 1.12 1.17 1.07
Only index persons 1.35 1.38 1.31
Median age at first event (years)
Whole population 42.31 42.25 42.39
Only index persons 43.52 43.50 43.54

-FinnGen-

Key figures

All Female Male
Number of individuals 8455 4849 3606
Unadjusted period prevalence (%) 1.86 1.90 1.81
Median age at first event (years) 51.73 48.28 56.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H8_EXTOTITIS and mortality.

Females

Parameter HR [95% CI] p-value
H8_EXTOTITIS 1.27 [1.14, 1.42] < 0.001
Birth year 1.0 [0.99, 1.01] 0.94

During the follow-up period (1.1.1998 — 31.12.2019), 3046 out of 30502 females with H8_EXTOTITIS died.

Males

Parameter HR [95% CI] p-value
H8_EXTOTITIS 1.27 [1.14, 1.41] < 0.001
Birth year 0.989 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 3871 out of 28188 males with H8_EXTOTITIS died.

Mortality risk

Mortality risk for people of age

years, who have H8_EXTOTITIS.

N-year risk Females Males
1 0.12% 0.237%
5 0.809% 1.513%
10 2.066% 3.794%
15 4.113% 7.304%
20 7.259% 12.046%

Relationships between endpoints

Index endpoint: H8_EXTOTITIS – Otitis externa

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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