Abscess of external ear

H8_EXT_ABSC

otitis externa: Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H60.0
  • Hospital discharge: ICD-8 3800[0-1]
  • Cause of death: ICD-10 H60.0
  • Cause of death: ICD-8 3800[0-1]

2 out of 7 registries used, show all original rules.

477

4. Check minimum number of events

None

477

5. Include endpoints

None

477

6. Filter based on genotype QC (FinnGen only)

452

Control definitions (FinnGen only)

Control exclude H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H60
Name in latin Abscessus auris externae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5026 2233 2766
Only index persons 4591 2057 2534
Unadjusted period prevalence (%)
Whole population 0.07 0.06 0.08
Only index persons 0.09 0.08 0.10
Median age at first event (years)
Whole population 34.04 36.08 32.27
Only index persons 33.71 36.09 31.77

-FinnGen-

Key figures

All Female Male
Number of individuals 452 240 212
Unadjusted period prevalence (%) 0.10 0.09 0.11
Median age at first event (years) 41.96 39.34 44.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H8_EXT_ABSC and mortality.

Females

Parameter HR [95% CI] p-value
H8_EXT_ABSC 1.518 [1.23, 1.88] < 0.001
Birth year 0.997 [0.99, 1.01] 0.427

During the follow-up period (1.1.1998 — 31.12.2019), 227 out of 1895 females with H8_EXT_ABSC died.

Males

Parameter HR [95% CI] p-value
H8_EXT_ABSC 1.552 [1.3, 1.85] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 326 out of 2212 males with H8_EXT_ABSC died.

Mortality risk

Mortality risk for people of age

years, who have H8_EXT_ABSC.

N-year risk Females Males
1 0.136% 0.284%
5 0.798% 1.831%
10 2.06% 4.494%
15 4.252% 8.106%
20 7.656% 13.681%

Relationships between endpoints

Index endpoint: H8_EXT_ABSC – Abscess of external ear

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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