otitis externa: Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
538 |
4. Check minimum number of eventsNone |
538 |
5. Include endpointsNone |
538 |
6. Filter based on genotype QC (FinnGen only) |
519 |
Control definitions (FinnGen only)
Control exclude
H8_EXTERNAL
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H60
Name in latin
Otitis externa acuta non infectiosa
Similar endpoints
↥List of similar endpoints to
Acute otitis externa, noninfective
based on the number of shared cases.
Similar with more cases:
- Otitis externa
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4704 | 2439 | 2237 |
| Only index persons | 4262 | 2271 | 1991 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.06 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 45.42 | 45.65 | 45.04 |
| Only index persons | 44.12 | 44.57 | 43.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 519 | 309 | 210 |
| Unadjusted period prevalence (%) | 0.11 | 0.12 | 0.11 |
| Median age at first event (years) | 48.99 | 48.24 | 50.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_EXT_NONINF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_NONINF | 1.437 [1.24, 1.66] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 2245 females with H8_EXT_NONINF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_NONINF | 1.369 [1.2, 1.56] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 486 out of 2048 males with H8_EXT_NONINF died.
Mortality risk
Mortality risk for people of age
years, who have H8_EXT_NONINF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.152% | 0.252% |
| 5 | 0.83% | 1.636% |
| 10 | 2.1% | 4.116% |
| 15 | 3.908% | 7.577% |
| 20 | 6.395% | 13.316% |
Relationships between endpoints
↥Index endpoint: H8_EXT_NONINF – Acute otitis externa, noninfective
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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