Other infective otitis externa

H8_EXT_INFNAS

otitis externa: Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H60.3
  • Cause of death: ICD-10 H60.3

2 out of 7 registries used, show all original rules.

2110

4. Check minimum number of events

None

2110

5. Include endpoints

None

2110

6. Filter based on genotype QC (FinnGen only)

2021

Control definitions (FinnGen only)

Control exclude H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H60
Name in latin Alia otitis externa infectiosa

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 16526 8526 7935
Only index persons 15476 8098 7378
Unadjusted period prevalence (%)
Whole population 0.23 0.24 0.22
Only index persons 0.29 0.30 0.28
Median age at first event (years)
Whole population 46.95 45.50 48.53
Only index persons 47.01 45.65 48.51

-FinnGen-

Key figures

All Female Male
Number of individuals 2021 1130 891
Unadjusted period prevalence (%) 0.45 0.44 0.45
Median age at first event (years) 52.83 48.32 58.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H8_EXT_INFNAS and mortality.

Females

Parameter HR [95% CI] p-value
H8_EXT_INFNAS 1.229 [1.08, 1.4] 0.001
Birth year 0.996 [0.99, 1.0] 0.402

During the follow-up period (1.1.1998 — 31.12.2019), 922 out of 7274 females with H8_EXT_INFNAS died.

Males

Parameter HR [95% CI] p-value
H8_EXT_INFNAS 1.296 [1.15, 1.46] < 0.001
Birth year 0.99 [0.98, 1.0] 0.025

During the follow-up period (1.1.1998 — 31.12.2019), 1222 out of 6899 males with H8_EXT_INFNAS died.

Mortality risk

Mortality risk for people of age

years, who have H8_EXT_INFNAS.

N-year risk Females Males
1 0.084% 0.247%
5 0.761% 1.604%
10 1.791% 4.07%
15 3.653% 7.977%
20 6.526% 13.166%

Relationships between endpoints

Index endpoint: H8_EXT_INFNAS – Other infective otitis externa

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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