Cholesteatoma of external ear

H8_EXT_CHOL

cholesteatoma of external ear: A cholesteatoma which involves invasion of the squamous tissue into a localized area of bony erosion of the ear canal. It may develop spontaneously or as a consequence of infection, trauma or surgery.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H60.4
  • Cause of death: ICD-10 H60.4

2 out of 7 registries used, show all original rules.

222

4. Check minimum number of events

None

222

5. Include endpoints

None

222

6. Filter based on genotype QC (FinnGen only)

211

Control definitions (FinnGen only)

Control exclude H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H60
Name in latin Cholesteatoma meatus acustici externi

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2037 1011 1016
Only index persons 1930 964 966
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 64.36 65.08 63.74
Only index persons 63.84 64.05 63.64

-FinnGen-

Key figures

All Female Male
Number of individuals 211 88 123
Unadjusted period prevalence (%) 0.05 0.03 0.06
Median age at first event (years) 66.15 64.00 67.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H8_EXT_CHOL and mortality.

Females

Parameter HR [95% CI] p-value
H8_EXT_CHOL 1.283 [1.02, 1.62] 0.035
Birth year 0.998 [0.99, 1.01] 0.613

During the follow-up period (1.1.1998 — 31.12.2019), 222 out of 870 females with H8_EXT_CHOL died.

Males

Parameter HR [95% CI] p-value
H8_EXT_CHOL 1.268 [1.01, 1.6] 0.043
Birth year 0.99 [0.98, 1.0] 0.031

During the follow-up period (1.1.1998 — 31.12.2019), 225 out of 883 males with H8_EXT_CHOL died.

Mortality risk

Mortality risk for people of age

years, who have H8_EXT_CHOL.

N-year risk Females Males
1 0.122% 0.26%
5 0.774% 1.499%
10 2.0% 3.783%
15 3.865% 7.259%
20 6.95% 12.422%

Relationships between endpoints

Index endpoint: H8_EXT_CHOL – Cholesteatoma of external ear

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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