cholesteatoma of external ear: A cholesteatoma which involves invasion of the squamous tissue into a localized area of bony erosion of the ear canal. It may develop spontaneously or as a consequence of infection, trauma or surgery.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
222 |
4. Check minimum number of eventsNone |
222 |
5. Include endpointsNone |
222 |
6. Filter based on genotype QC (FinnGen only) |
211 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Cholesteatoma of external ear based on the number of shared cases.
Similar with more cases:
- Otitis externa
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 2037 | 1011 | 1016 |
Only index persons | 1930 | 964 | 966 |
Unadjusted period prevalence (%) | |||
Whole population | 0.03 | 0.03 | 0.03 |
Only index persons | 0.04 | 0.04 | 0.04 |
Median age at first event (years) | |||
Whole population | 64.36 | 65.08 | 63.74 |
Only index persons | 63.84 | 64.05 | 63.64 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 211 | 88 | 123 |
Unadjusted period prevalence (%) | 0.05 | 0.03 | 0.06 |
Median age at first event (years) | 66.15 | 64.00 | 67.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_EXT_CHOL and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
H8_EXT_CHOL | 1.283 [1.02, 1.62] | 0.035 |
Birth year | 0.998 [0.99, 1.01] | 0.613 |
During the follow-up period (1.1.1998 — 31.12.2019), 222 out of 870 females with H8_EXT_CHOL died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
H8_EXT_CHOL | 1.268 [1.01, 1.6] | 0.043 |
Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 225 out of 883 males with H8_EXT_CHOL died.
Mortality risk
Mortality risk for people of age
years, who have H8_EXT_CHOL.N-year risk | Females | Males |
---|---|---|
1 | 0.122% | 0.26% |
5 | 0.774% | 1.499% |
10 | 2.0% | 3.783% |
15 | 3.865% | 7.259% |
20 | 6.95% | 12.422% |
Relationships between endpoints
↥Index endpoint: H8_EXT_CHOL – Cholesteatoma of external ear
GWS hits: 1