Other specified disorders of external ear

H8_EXTDISNAS

external ear disease: A disease involving the external ear. [database_cross_reference: MONDO:DesignPattern]

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H61.8, H61.9
  • Hospital discharge: ICD-9 380[8-9]
  • Cause of death: ICD-10 H61.8, H61.9
  • Cause of death: ICD-9 380[8-9]

2 out of 7 registries used, show all original rules.

1150

4. Check minimum number of events

None

1150

5. Include endpoints

None

1150

6. Filter based on genotype QC (FinnGen only)

1107

Control definitions (FinnGen only)

Control exclude H8_EXTERNAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8281 2364 5883
Only index persons 7659 2206 5453
Unadjusted period prevalence (%)
Whole population 0.14 0.07 0.16
Only index persons 0.17 0.08 0.21
Median age at first event (years)
Whole population 54.74 53.01 55.43
Only index persons 55.12 53.64 55.72

-FinnGen-

Key figures

All Female Male
Number of individuals 1107 276 831
Unadjusted period prevalence (%) 0.34 0.11 0.42
Median age at first event (years) 59.82 58.52 60.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H8_EXTDISNAS and mortality.

Females

Parameter HR [95% CI] p-value
H8_EXTDISNAS 1.237 [1.0, 1.53] 0.05
Birth year 0.992 [0.98, 1.0] 0.063

During the follow-up period (1.1.1998 — 31.12.2019), 211 out of 1882 females with H8_EXTDISNAS died.

Males

Parameter HR [95% CI] p-value
H8_EXTDISNAS 0.863 [0.76, 0.98] 0.02
Birth year 0.988 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 652 out of 4632 males with H8_EXTDISNAS died.

Mortality risk

Mortality risk for people of age

years, who have H8_EXTDISNAS.

N-year risk Females Males
1 0.1% 0.141%
5 0.707% 1.015%
10 1.709% 2.44%
15 3.23% 4.766%
20 5.448% 8.588%

Relationships between endpoints

Index endpoint: H8_EXTDISNAS – Other specified disorders of external ear

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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