No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersCheck mode of ICD-10 codes: %J451 Registry filters: 2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
J10_ASTHMA, ALLERG_ASTHMA, VOCALCORDDYS, I9_HEARTFAIL, J10_HYPERSPNEUMONI, ASTHMA_EXCL
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Non-allergic asthma (mode)
based on the number of shared cases.
Similar with more cases:
- Non-allergic asthma (mode)
- Asthma
- Asthma
- Asthma, including avohilmo
- Chronic lower respiratory diseases
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 97867 | 48629 | 48859 |
| Only index persons | 81836 | 42335 | 39501 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.38 | 1.39 | 1.37 |
| Only index persons | 1.53 | 1.56 | 1.51 |
| Median age at first event (years) | |||
| Whole population | 29.70 | 45.06 | 14.11 |
| Only index persons | 34.37 | 46.04 | 21.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8505 | 5073 | 3432 |
| Unadjusted period prevalence (%) | 1.88 | 1.99 | 1.72 |
| Median age at first event (years) | 53.41 | 51.25 | 56.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint NONALLERG_ASTHMA_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| NONALLERG_ASTHMA_EXMORE | 1.408 [1.31, 1.51] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.122 |
During the follow-up period (1.1.1998 — 31.12.2019), 6235 out of 44138 females with NONALLERG_ASTHMA_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| NONALLERG_ASTHMA_EXMORE | 1.532 [1.42, 1.66] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 6793 out of 44550 males with NONALLERG_ASTHMA_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have NONALLERG_ASTHMA_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.139% | 0.274% |
| 5 | 0.82% | 1.794% |
| 10 | 1.939% | 4.653% |
| 15 | 3.78% | 8.627% |
| 20 | 6.508% | 14.443% |
Relationships between endpoints
↥Index endpoint: NONALLERG_ASTHMA_EXMORE – Non-allergic asthma (mode)
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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