human african trypanosomiasis: A parasitic disorder caused by protozoa of the Trypanosoma brucei species. It is transmitted by flies and is endemic in various regions of Sub-Saharan Africa. Signs and symptoms include fever, joint pain, headache, and significant swelling of the lymph nodes. If left untreated, the parasitic infection causes anemia, heart, kidney, and endocrine failure, and neurologic damage. Subsequently patients develop confusion, disruption of the sleep cycle, and mental deterioration. The infection may lead to coma and death.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
6442 |
4. Check minimum number of eventsNone |
6442 |
5. Include endpointsNone |
6442 |
6. Filter based on genotype QC (FinnGen only) |
6203 |
Control definitions (FinnGen only)
Control exclude
ASTHMA_COMORB
Extra metadata
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
J38
Similar endpoints
↥List of similar endpoints to
Vocal cord dysfunction
based on the number of shared cases.
Similar with more cases:
- Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified
- Other diseases of upper respiratory tract
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 42520 | 24121 | 18181 |
| Only index persons | 38879 | 22738 | 16141 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.61 | 0.69 | 0.51 |
| Only index persons | 0.74 | 0.84 | 0.62 |
| Median age at first event (years) | |||
| Whole population | 52.45 | 51.19 | 53.98 |
| Only index persons | 51.86 | 50.83 | 53.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6203 | 3831 | 2372 |
| Unadjusted period prevalence (%) | 1.38 | 1.50 | 1.19 |
| Median age at first event (years) | 54.52 | 51.13 | 59.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint VOCALCORDDYS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VOCALCORDDYS | 1.737 [1.58, 1.91] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.223 |
During the follow-up period (1.1.1998 — 31.12.2019), 3227 out of 21177 females with VOCALCORDDYS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VOCALCORDDYS | 1.823 [1.66, 2.0] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 3762 out of 15769 males with VOCALCORDDYS died.
Mortality risk
Mortality risk for people of age
years, who have VOCALCORDDYS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.158% | 0.418% |
| 5 | 1.028% | 2.325% |
| 10 | 2.726% | 5.509% |
| 15 | 4.727% | 10.609% |
| 20 | 8.034% | 17.177% |
Relationships between endpoints
↥Index endpoint: VOCALCORDDYS – Vocal cord dysfunction
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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