No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
80091 |
4. Check minimum number of eventsNone |
80091 |
5. Include endpoints |
119889 |
6. Filter based on genotype QC (FinnGen only) |
115852 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Other diseases of upper respiratory tract
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1214797 | 594962 | 615238 |
| Only index persons | 1106993 | 553534 | 553459 |
| Unadjusted period prevalence (%) | |||
| Whole population | 17.07 | 17.04 | 17.19 |
| Only index persons | 20.74 | 20.35 | 21.13 |
| Median age at first event (years) | |||
| Whole population | 19.50 | 21.13 | 17.78 |
| Only index persons | 19.75 | 21.45 | 18.05 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 115852 | 69510 | 46342 |
| Unadjusted period prevalence (%) | 25.69 | 27.30 | 23.27 |
| Median age at first event (years) | 29.85 | 27.10 | 33.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_UPPERDIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_UPPERDIS | 1.088 [0.99, 1.2] | 0.081 |
| Birth year | 0.997 [0.99, 1.0] | 0.418 |
During the follow-up period (1.1.1998 — 31.12.2019), 14268 out of 301390 females with J10_UPPERDIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_UPPERDIS | 1.073 [0.98, 1.17] | 0.12 |
| Birth year | 0.986 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 19941 out of 308838 males with J10_UPPERDIS died.
Mortality risk
Mortality risk for people of age
years, who have J10_UPPERDIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.067% | 0.202% |
| 5 | 0.59% | 1.093% |
| 10 | 1.547% | 2.78% |
| 15 | 3.131% | 5.417% |
| 20 | 5.62% | 9.36% |
Relationships between endpoints
↥Index endpoint: J10_UPPERDIS – Other diseases of upper respiratory tract
GWS hits: 40
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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