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Chronic diseases of tonsils and adenoids

DOID EFO Endpoint Browser PheWeb

J10_CHRONTONSADEN

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J35
  • Hospital discharge: ICD-9 — 474
  • Hospital discharge: ICD-8 — 500
  • Cause of death: ICD-10 — J35
  • Cause of death: ICD-9 — 474
  • Cause of death: ICD-8 — 500

2 out of 7 registries used, show all original rules.

55559

4. Check minimum number of events

None

55559

5. Include endpoints

None

55559

6. Filter based on genotype QC (FinnGen only)

53926

Control definitions (FinnGen only)

Control exclude J10_UPPERDIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J30-J39
Name in latin Morbi chronici tonsillarum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 644090 326981 315902
Only index persons 595221 306055 289166
Unadjusted period prevalence (%)
Whole population 9.09 9.37 8.83
Only index persons 11.15 11.25 11.04
Median age at first event (years)
Whole population 9.36 12.07 6.49
Only index persons 9.84 12.79 6.71

-FinnGen-

Key figures

All Female Male
Number of individuals 53926 35757 18169
Unadjusted period prevalence (%) 12.39 14.04 9.12
Median age at first event (years) 15.72 16.76 13.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint J10_CHRONTONSADEN and mortality.

Females

Parameter HR [95% CI] p-value
J10_CHRONTONSADEN 0.939 [0.82, 1.08] 0.37
Birth year 0.993 [0.98, 1.0] 0.093

During the follow-up period (1.1.1998 — 31.12.2019), 1451 out of 124716 females with J10_CHRONTONSADEN died.

Males

Parameter HR [95% CI] p-value
J10_CHRONTONSADEN 0.931 [0.81, 1.07] 0.325
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 1631 out of 122457 males with J10_CHRONTONSADEN died.

Mortality risk

Mortality risk for people of age

years, who have J10_CHRONTONSADEN.

N-year risk Females Males
1 0.083% 0.156%
5 0.521% 0.991%
10 1.259% 2.597%
15 2.596% 4.863%
20 4.558% 8.206%

Relationships between endpoints

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Index endpoint: J10_CHRONTONSADEN – Chronic diseases of tonsils and adenoids

GWS hits: 62

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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