Deviated nasal septum

J10_SEPTDEV

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J34.2
  • Hospital discharge: ICD-9 470
  • Hospital discharge: ICD-8 50499
  • Cause of death: ICD-10 J34.2
  • Cause of death: ICD-9 470
  • Cause of death: ICD-8 50499

2 out of 7 registries used, show all original rules.

14750

4. Check minimum number of events

None

14750

5. Include endpoints

None

14750

6. Filter based on genotype QC (FinnGen only)

14172

Control definitions (FinnGen only)

Control exclude J10_UPPERDIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J34
Name in latin Deviatio septi nasi

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 113104 32492 79819
Only index persons 105171 31053 74118
Unadjusted period prevalence (%)
Whole population 1.85 0.93 2.23
Only index persons 2.33 1.14 2.83
Median age at first event (years)
Whole population 39.81 40.32 39.60
Only index persons 39.33 40.01 39.05

-FinnGen-

Key figures

All Female Male
Number of individuals 14172 4939 9233
Unadjusted period prevalence (%) 3.70 1.94 4.64
Median age at first event (years) 42.77 40.73 43.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint J10_SEPTDEV and mortality.

Females

Parameter HR [95% CI] p-value
J10_SEPTDEV 0.918 [0.82, 1.03] 0.141
Birth year 0.996 [0.99, 1.0] 0.343

During the follow-up period (1.1.1998 — 31.12.2019), 877 out of 18883 females with J10_SEPTDEV died.

Males

Parameter HR [95% CI] p-value
J10_SEPTDEV 0.772 [0.71, 0.84] < 0.001
Birth year 0.991 [0.98, 1.0] 0.073

During the follow-up period (1.1.1998 — 31.12.2019), 3369 out of 47311 males with J10_SEPTDEV died.

Mortality risk

Mortality risk for people of age

years, who have J10_SEPTDEV.

N-year risk Females Males
1 0.081% 0.153%
5 0.472% 1.035%
10 1.306% 2.599%
15 2.7% 4.934%
20 4.722% 8.481%

Relationships between endpoints

Index endpoint: J10_SEPTDEV – Deviated nasal septum

GWS hits: 6

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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