Chronic rhinitis, nasopharyngitis and pharyngitis

J10_CHRONRHINITIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J31
  • Hospital discharge: ICD-9 472
  • Hospital discharge: ICD-8 502
  • Cause of death: ICD-10 J31
  • Cause of death: ICD-9 472
  • Cause of death: ICD-8 502

2 out of 7 registries used, show all original rules.

14049

4. Check minimum number of events

None

14049

5. Include endpoints

None

14049

6. Filter based on genotype QC (FinnGen only)

13519

Control definitions (FinnGen only)

Control exclude J10_UPPERDIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J30-J39
Name in latin Rhinitis/nasopharyngitis/pharyngitis chronica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 95366 53491 41359
Only index persons 90114 51482 38632
Unadjusted period prevalence (%)
Whole population 1.36 1.53 1.16
Only index persons 1.71 1.89 1.47
Median age at first event (years)
Whole population 44.12 45.89 41.93
Only index persons 44.65 46.12 42.69

-FinnGen-

Key figures

All Female Male
Number of individuals 13519 8767 4752
Unadjusted period prevalence (%) 3.07 3.44 2.39
Median age at first event (years) 50.19 48.85 52.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint J10_CHRONRHINITIS and mortality.

Females

Parameter HR [95% CI] p-value
J10_CHRONRHINITIS 0.923 [0.83, 1.02] 0.125
Birth year 0.994 [0.99, 1.0] 0.161

During the follow-up period (1.1.1998 — 31.12.2019), 2598 out of 44109 females with J10_CHRONRHINITIS died.

Males

Parameter HR [95% CI] p-value
J10_CHRONRHINITIS 0.874 [0.79, 0.97] 0.011
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 2649 out of 34035 males with J10_CHRONRHINITIS died.

Mortality risk

Mortality risk for people of age

years, who have J10_CHRONRHINITIS.

N-year risk Females Males
1 0.081% 0.18%
5 0.535% 1.043%
10 1.389% 2.557%
15 2.532% 4.996%
20 4.399% 8.207%

Relationships between endpoints

Index endpoint: J10_CHRONRHINITIS – Chronic rhinitis, nasopharyngitis and pharyngitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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