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Nasal polyp

EFO MESH Endpoint Browser PheWeb

J10_NASALPOLYP

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J33
  • Hospital discharge: ICD-9 — 471
  • Hospital discharge: ICD-8 — 505
  • Cause of death: ICD-10 — J33
  • Cause of death: ICD-9 — 471
  • Cause of death: ICD-8 — 505

2 out of 7 registries used, show all original rules.

7799

4. Check minimum number of events

None

7799

5. Include endpoints

None

7799

6. Filter based on genotype QC (FinnGen only)

7563

Control definitions (FinnGen only)

Control exclude J10_UPPERDIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J30-J39
Name in latin Polypus nasi

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 59117 20506 38226
Only index persons 53927 19156 34771
Unadjusted period prevalence (%)
Whole population 0.90 0.59 1.07
Only index persons 1.11 0.70 1.33
Median age at first event (years)
Whole population 50.67 48.92 51.58
Only index persons 49.79 48.11 50.71

-FinnGen-

Key figures

All Female Male
Number of individuals 7563 2922 4641
Unadjusted period prevalence (%) 1.87 1.15 2.33
Median age at first event (years) 50.73 46.31 53.51

-FinRegistry-

Age distribution of first events

01020304050607080900k1k2k3k4k5k6k7k8k9k10k11k12k13k14kAgeIndividuals

-FinnGen-

Age distribution of first events

010203040506070800.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6k1.8kAgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220k1k2k3k4k5k6k7k8k9kYearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230.0k0.1k0.2k0.3k0.4k0.5k0.6k0.7k0.8k0.9k1.0k1.1k1.2kYearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.51.01.52.02.53.03.54.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.51.01.52.02.53.03.54.04.55.0AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint J10_NASALPOLYP and mortality.

Females

Parameter HR [95% CI] p-value
J10_NASALPOLYP 0.915 [0.83, 1.01] 0.074
Birth year 0.996 [0.99, 1.0] 0.359

During the follow-up period (1.1.1998 — 31.12.2019), 1298 out of 14093 females with J10_NASALPOLYP died.

Males

Parameter HR [95% CI] p-value
J10_NASALPOLYP 0.848 [0.78, 0.92] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 3609 out of 26939 males with J10_NASALPOLYP died.

Mortality risk

Mortality risk for people of age

years, who have J10_NASALPOLYP.

N-year risk Females Males
1 0.08% 0.169%
5 0.484% 0.807%
10 1.265% 2.158%
15 2.553% 4.254%
20 4.582% 7.509%

Relationships between endpoints

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Index endpoint: J10_NASALPOLYP – Nasal polyp

GWS hits: 36

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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