sinusitis: An acute or chronic inflammatory process affecting the mucous membranes of any sinus cavity.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
20471 |
4. Check minimum number of eventsNone |
20471 |
5. Include endpointsNone |
20471 |
6. Filter based on genotype QC (FinnGen only) |
19856 |
Control definitions (FinnGen only)
Control exclude
J10_UPPERDIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J30-J39
Name in latin
Sinuitis chronica
Similar endpoints
↥List of similar endpoints to
Chronic sinusitis
based on the number of shared cases.
Similar with more cases:
- Other diseases of upper respiratory tract
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 149231 | 81988 | 66376 |
| Only index persons | 135548 | 76239 | 59309 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.12 | 2.35 | 1.85 |
| Only index persons | 2.57 | 2.80 | 2.26 |
| Median age at first event (years) | |||
| Whole population | 41.12 | 41.82 | 40.14 |
| Only index persons | 39.67 | 40.74 | 38.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 19856 | 12434 | 7422 |
| Unadjusted period prevalence (%) | 4.45 | 4.88 | 3.73 |
| Median age at first event (years) | 43.02 | 41.33 | 45.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_CHRONSINUSITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_CHRONSINUSITIS | 0.982 [0.9, 1.08] | 0.706 |
| Birth year | 0.994 [0.99, 1.0] | 0.116 |
During the follow-up period (1.1.1998 — 31.12.2019), 3257 out of 50262 females with J10_CHRONSINUSITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_CHRONSINUSITIS | 0.944 [0.86, 1.03] | 0.201 |
| Birth year | 0.992 [0.98, 1.0] | 0.066 |
During the follow-up period (1.1.1998 — 31.12.2019), 3459 out of 36289 males with J10_CHRONSINUSITIS died.
Mortality risk
Mortality risk for people of age
years, who have J10_CHRONSINUSITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.205% |
| 5 | 0.538% | 1.188% |
| 10 | 1.305% | 3.293% |
| 15 | 2.557% | 6.208% |
| 20 | 4.558% | 10.149% |
Relationships between endpoints
↥Index endpoint: J10_CHRONSINUSITIS – Chronic sinusitis
GWS hits: 20
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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