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Chronic laryngitis and laryngotracheitis

DOID EFO Endpoint Browser PheWeb

J10_CHRONLARYNGITIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J37
  • Hospital discharge: ICD-9 — 476
  • Hospital discharge: ICD-8 — 506
  • Cause of death: ICD-10 — J37
  • Cause of death: ICD-9 — 476
  • Cause of death: ICD-8 — 506

2 out of 7 registries used, show all original rules.

5424

4. Check minimum number of events

None

5424

5. Include endpoints

None

5424

6. Filter based on genotype QC (FinnGen only)

5227

Control definitions (FinnGen only)

Control exclude J10_UPPERDIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J30-J39
Name in latin Laryngitis/laryngotracheitis chronica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 31693 16193 15230
Only index persons 27734 15236 12498
Unadjusted period prevalence (%)
Whole population 0.44 0.46 0.43
Only index persons 0.52 0.56 0.48
Median age at first event (years)
Whole population 53.46 52.54 54.37
Only index persons 52.71 52.16 53.39

-FinnGen-

Key figures

All Female Male
Number of individuals 5227 3049 2178
Unadjusted period prevalence (%) 1.15 1.20 1.09
Median age at first event (years) 55.36 53.20 58.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint J10_CHRONLARYNGITIS and mortality.

Females

Parameter HR [95% CI] p-value
J10_CHRONLARYNGITIS 1.436 [1.29, 1.6] < 0.001
Birth year 0.993 [0.98, 1.0] 0.125

During the follow-up period (1.1.1998 — 31.12.2019), 1524 out of 12475 females with J10_CHRONLARYNGITIS died.

Males

Parameter HR [95% CI] p-value
J10_CHRONLARYNGITIS 1.619 [1.48, 1.77] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 2455 out of 10201 males with J10_CHRONLARYNGITIS died.

Mortality risk

Mortality risk for people of age

years, who have J10_CHRONLARYNGITIS.

N-year risk Females Males
1 0.16% 0.324%
5 0.769% 2.021%
10 2.059% 4.777%
15 3.884% 8.898%
20 6.697% 14.637%

Relationships between endpoints

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Index endpoint: J10_CHRONLARYNGITIS – Chronic laryngitis and laryngotracheitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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