laryngeal disease: A non-neoplastic or neoplastic disorder that affects the larynx. Representative examples include laryngitis, vocal cord polyp, squamous papilloma, and carcinoma. [database_cross_reference: NCIT:P378]
Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified
DOID EFO Endpoint Browser PheWeb
J10_VOCALLARYNX
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
25040 |
4. Check minimum number of eventsNone |
25040 |
5. Include endpointsNone |
25040 |
6. Filter based on genotype QC (FinnGen only) |
24080 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified based on the number of shared cases.
Similar with more cases:
- Other diseases of upper respiratory tract
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 183260 | 79082 | 103086 |
Only index persons | 171084 | 74969 | 96115 |
Unadjusted period prevalence (%) | |||
Whole population | 2.60 | 2.27 | 2.88 |
Only index persons | 3.27 | 2.76 | 3.67 |
Median age at first event (years) | |||
Whole population | 44.55 | 45.84 | 43.58 |
Only index persons | 44.03 | 45.38 | 42.98 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 24080 | 12168 | 11912 |
Unadjusted period prevalence (%) | 5.37 | 4.78 | 5.98 |
Median age at first event (years) | 48.17 | 46.67 | 49.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_VOCALLARYNX and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
J10_VOCALLARYNX | 1.312 [1.2, 1.43] | < 0.001 |
Birth year | 0.992 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 5821 out of 61488 females with J10_VOCALLARYNX died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
J10_VOCALLARYNX | 1.177 [1.08, 1.28] | < 0.001 |
Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 9050 out of 81771 males with J10_VOCALLARYNX died.
Mortality risk
Mortality risk for people of age
years, who have J10_VOCALLARYNX.N-year risk | Females | Males |
---|---|---|
1 | 0.13% | 0.207% |
5 | 0.667% | 1.239% |
10 | 1.721% | 2.841% |
15 | 3.187% | 5.631% |
20 | 5.836% | 9.63% |
Relationships between endpoints
↥Index endpoint: J10_VOCALLARYNX – Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified
GWS hits: 1