Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified

J10_VOCALLARYNX

laryngeal disease: A non-neoplastic or neoplastic disorder that affects the larynx. Representative examples include laryngitis, vocal cord polyp, squamous papilloma, and carcinoma. [database_cross_reference: NCIT:P378]

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J34, J38, J39
  • Hospital discharge: ICD-9 478
  • Hospital discharge: ICD-8 508
  • Hospital discharge: excluded ICD-8 50803
  • Cause of death: ICD-10 J34, J38, J39
  • Cause of death: ICD-9 478
  • Cause of death: ICD-8 508
  • Cause of death: excluded ICD-8 50803

2 out of 7 registries used, show all original rules.

25040

4. Check minimum number of events

None

25040

5. Include endpoints

None

25040

6. Filter based on genotype QC (FinnGen only)

24080

Control definitions (FinnGen only)

Control exclude J10_UPPERDIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 183260 79082 103086
Only index persons 171084 74969 96115
Unadjusted period prevalence (%)
Whole population 2.60 2.27 2.88
Only index persons 3.27 2.76 3.67
Median age at first event (years)
Whole population 44.55 45.84 43.58
Only index persons 44.03 45.38 42.98

-FinnGen-

Key figures

All Female Male
Number of individuals 24080 12168 11912
Unadjusted period prevalence (%) 5.37 4.78 5.98
Median age at first event (years) 48.17 46.67 49.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint J10_VOCALLARYNX and mortality.

Females

Parameter HR [95% CI] p-value
J10_VOCALLARYNX 1.312 [1.2, 1.43] < 0.001
Birth year 0.992 [0.98, 1.0] 0.037

During the follow-up period (1.1.1998 — 31.12.2019), 5821 out of 61488 females with J10_VOCALLARYNX died.

Males

Parameter HR [95% CI] p-value
J10_VOCALLARYNX 1.177 [1.08, 1.28] < 0.001
Birth year 0.984 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 9050 out of 81771 males with J10_VOCALLARYNX died.

Mortality risk

Mortality risk for people of age

years, who have J10_VOCALLARYNX.

N-year risk Females Males
1 0.13% 0.207%
5 0.667% 1.239%
10 1.721% 2.841%
15 3.187% 5.631%
20 5.836% 9.63%

Relationships between endpoints

Index endpoint: J10_VOCALLARYNX – Diseases of vocal cords and larynx+other diseases of upper respiratory tract, no elsewhere classified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data