extrinsic allergic alveolitis: An inflammatory interstitial lung disease caused by hypersensitivity reaction to inhalation or ingestion of antigens. The antigens are usually related to the patient's occupation. It can present as an acute illness with flu-like symptoms, subacute with repeated episodes of pneumonia, or chronic with dyspnea and productive cough. The majority of patients recover following the cessation of the exposure to the antigen that causes the disease. Chronic exposure may eventually progress to interstitial lung fibrosis.
Hypersensitivity pneumonitis due to organic dust
DOID EFO Endpoint Browser PheWeb
J10_HYPERSPNEUMONI
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
533 |
4. Check minimum number of eventsNone |
533 |
5. Include endpointsNone |
533 |
6. Filter based on genotype QC (FinnGen only) |
523 |
Control definitions (FinnGen only)
Control exclude
J10_EXTERLUNG
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J60-J70
Name in latin
Pneumonitis/alveolitis hypersensitiva e pulvere organico
Similar endpoints
↥List of similar endpoints to
Hypersensitivity pneumonitis due to organic dust
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5824 | 2873 | 2887 |
| Only index persons | 4602 | 2341 | 2261 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 52.93 | 53.15 | 52.37 |
| Only index persons | 49.96 | 50.96 | 48.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 523 | 267 | 256 |
| Unadjusted period prevalence (%) | 0.12 | 0.10 | 0.13 |
| Median age at first event (years) | 49.13 | 46.79 | 51.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint J10_HYPERSPNEUMONI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_HYPERSPNEUMONI | 1.979 [1.7, 2.31] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 1173 females with J10_HYPERSPNEUMONI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_HYPERSPNEUMONI | 1.516 [1.31, 1.76] | < 0.001 |
| Birth year | 0.985 [0.97, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 1282 males with J10_HYPERSPNEUMONI died.
Mortality risk
Mortality risk for people of age
years, who have J10_HYPERSPNEUMONI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.223% | 0.299% |
| 5 | 1.17% | 1.727% |
| 10 | 2.856% | 4.114% |
| 15 | 5.534% | 7.983% |
| 20 | 9.455% | 13.086% |
Relationships between endpoints
↥Index endpoint: J10_HYPERSPNEUMONI – Hypersensitivity pneumonitis due to organic dust
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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