No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
4857 |
4. Check minimum number of eventsNone |
4857 |
5. Include endpoints |
5316 |
6. Filter based on genotype QC (FinnGen only) |
5141 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Lung diseases due to external agents
based on the number of shared cases.
Similar with more cases:
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 65050 | 24383 | 39593 |
| Only index persons | 45747 | 17975 | 27772 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.95 | 0.70 | 1.11 |
| Only index persons | 0.90 | 0.66 | 1.06 |
| Median age at first event (years) | |||
| Whole population | 69.66 | 71.27 | 68.59 |
| Only index persons | 67.86 | 68.54 | 67.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5141 | 1630 | 3511 |
| Unadjusted period prevalence (%) | 1.41 | 0.64 | 1.76 |
| Median age at first event (years) | 66.74 | 59.82 | 69.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_EXTERLUNG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_EXTERLUNG | 3.808 [3.36, 4.31] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.541 |
During the follow-up period (1.1.1998 — 31.12.2019), 6547 out of 12360 females with J10_EXTERLUNG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_EXTERLUNG | 3.701 [3.25, 4.21] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 11681 out of 21009 males with J10_EXTERLUNG died.
Mortality risk
Mortality risk for people of age
years, who have J10_EXTERLUNG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.464% | 0.573% |
| 5 | 2.347% | 3.661% |
| 10 | 5.493% | 8.851% |
| 15 | 9.994% | 15.792% |
| 20 | 18.381% | 25.671% |
Relationships between endpoints
↥Index endpoint: J10_EXTERLUNG – Lung diseases due to external agents
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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