asbestosis: A pneumoconiosis caused by inhalation and retention of asbestos fibers.
Pneumoconiosis due to asbestos and other mineral fibres
DOID EFO Endpoint Browser PheWeb
J10_ASBESTPNEUMOC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
736 |
4. Check minimum number of eventsNone |
736 |
5. Include endpointsNone |
736 |
6. Filter based on genotype QC (FinnGen only) |
721 |
Control definitions (FinnGen only)
Control exclude
J10_EXTERLUNG
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J60-J70
Name in latin
Asbestosis
Similar endpoints
↥List of similar endpoints to
Pneumoconiosis due to asbestos and other mineral fibres
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6025 | 326 | 5496 |
| Only index persons | 3520 | 209 | 3311 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.01 | 0.15 |
| Only index persons | 0.12 | 0.01 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 71.18 | 71.89 | 71.13 |
| Only index persons | 71.74 | 71.88 | 71.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 721 | 26 | 695 |
| Unadjusted period prevalence (%) | 0.34 | 0.01 | 0.35 |
| Median age at first event (years) | 70.28 | 60.52 | 70.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_ASBESTPNEUMOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASBESTPNEUMOC | 1.687 [1.26, 2.25] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.642 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 200 females with J10_ASBESTPNEUMOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASBESTPNEUMOC | 1.879 [1.69, 2.09] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 2029 out of 3332 males with J10_ASBESTPNEUMOC died.
Mortality risk
Mortality risk for people of age
years, who have J10_ASBESTPNEUMOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.176% | 0.358% |
| 5 | 1.034% | 2.316% |
| 10 | 2.786% | 5.423% |
| 15 | 5.368% | 10.024% |
| 20 | 9.573% | 16.505% |
Relationships between endpoints
↥Index endpoint: J10_ASBESTPNEUMOC – Pneumoconiosis due to asbestos and other mineral fibres
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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