silicosis: Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20years) to low amounts of silica dust. Simple chronic silicosismay causepeople to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 yearsof exposure of higher levels of silica.Swelling of the lungsand other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica.The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
108 |
4. Check minimum number of eventsNone |
108 |
5. Include endpointsNone |
108 |
6. Filter based on genotype QC (FinnGen only) |
104 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to
Pneumoconiosis due to dust containing silica
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1139 | 103 | 997 |
| Only index persons | 595 | 70 | 525 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.00 | 0.03 |
| Only index persons | 0.02 | 0.00 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 64.26 | 62.16 | 64.36 |
| Only index persons | 62.00 | 51.82 | 63.36 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 104 | 9 | 95 |
| Unadjusted period prevalence (%) | 0.04 | 0.00 | 0.05 |
| Median age at first event (years) | 63.90 | 41.38 | 66.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_SILICAPNEUMOC and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_SILICAPNEUMOC | 1.875 [1.51, 2.33] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 466 males with J10_SILICAPNEUMOC died.
Mortality risk
Mortality risk for people of age
years, who have J10_SILICAPNEUMOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.447% |
| 5 | No data | 2.501% |
| 10 | No data | 5.67% |
| 15 | No data | 10.948% |
| 20 | No data | 18.021% |
Relationships between endpoints
↥Index endpoint: J10_SILICAPNEUMOC – Pneumoconiosis due to dust containing silica
GWS hits: -
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