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This is a non-core endpoint: only basic statistics are computed.

Coalworker pneumoconiosis

J10_COALPNEUMOC

anthracosis: A diffuse parenchymal lung disease caused by accumulation of inhaled CARBON or coal dust. The disease can progress from asymptomatic anthracosis to massive lung fibrosis. This lung lesion usually occurs in coal MINERS, but can be seen in urban dwellers and tobacco smokers.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J60
  • Hospital discharge: ICD-9 500
  • Cause of death: ICD-10 J60
  • Cause of death: ICD-9 500

2 out of 7 registries used, show all original rules.

24

4. Check minimum number of events

None

24

5. Include endpoints

None

24

6. Filter based on genotype QC (FinnGen only)

22

Control definitions (FinnGen only)

Control exclude J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J60-J70
Name in latin Anthracosis pulmonum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 237 70 160
Only index persons 147 47 100
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 66.66 62.39 68.05
Only index persons 57.89 56.57 58.52

-FinnGen-

Key figures

All Female Male
Number of individuals 22 9 13
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 61.95 56.57 65.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint J10_COALPNEUMOC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have J10_COALPNEUMOC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: J10_COALPNEUMOC – Coalworker pneumoconiosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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