No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2920 |
4. Check minimum number of eventsNone |
2920 |
5. Include endpointsNone |
2920 |
6. Filter based on genotype QC (FinnGen only) |
2814 |
Control definitions (FinnGen only)
Control exclude
J10_EXTERLUNG
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J60-J70
Name in latin
Pneumonitis ex inhalatione materiarum solidarum sive liquidarum
Similar endpoints
↥List of similar endpoints to
Pneumonitis due to solids and liquids
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 41557 | 15557 | 25376 |
| Only index persons | 29612 | 11342 | 18270 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.61 | 0.45 | 0.71 |
| Only index persons | 0.59 | 0.42 | 0.70 |
| Median age at first event (years) | |||
| Whole population | 73.64 | 77.32 | 71.37 |
| Only index persons | 73.14 | 76.95 | 70.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2814 | 826 | 1988 |
| Unadjusted period prevalence (%) | 0.80 | 0.32 | 1.00 |
| Median age at first event (years) | 71.35 | 65.51 | 73.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_PNEUMONISOLLIQ and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PNEUMONISOLLIQ | 5.008 [4.19, 5.99] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.762 |
During the follow-up period (1.1.1998 — 31.12.2019), 4625 out of 7739 females with J10_PNEUMONISOLLIQ died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PNEUMONISOLLIQ | 5.458 [4.51, 6.61] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 7664 out of 12966 males with J10_PNEUMONISOLLIQ died.
Mortality risk
Mortality risk for people of age
years, who have J10_PNEUMONISOLLIQ.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.382% | 0.948% |
| 5 | 3.355% | 5.324% |
| 10 | 8.338% | 12.43% |
| 15 | 15.089% | 23.066% |
| 20 | 25.524% | 37.068% |
Relationships between endpoints
↥Index endpoint: J10_PNEUMONISOLLIQ – Pneumonitis due to solids and liquids
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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