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Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours

EFO MESH Endpoint Browser PheWeb

J10_CHEMGASRESP

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J68
  • Hospital discharge: ICD-9 — 506
  • Hospital discharge: ICD-8 — 516[1-2]
  • Cause of death: ICD-10 — J68
  • Cause of death: ICD-9 — 506
  • Cause of death: ICD-8 — 516[1-2]

2 out of 7 registries used, show all original rules.

284

4. Check minimum number of events

None

284

5. Include endpoints

None

284

6. Filter based on genotype QC (FinnGen only)

270

Control definitions (FinnGen only)

Control exclude J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J60-J70
Name in latin Morbositates respiratoriae ex inhalatione chemicalium, gasorum, fumorum et vaporum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3900 1869 1984
Only index persons 2958 1403 1555
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.06
Only index persons 0.06 0.05 0.06
Median age at first event (years)
Whole population 46.70 48.34 45.06
Only index persons 43.67 45.69 41.84

-FinnGen-

Key figures

All Female Male
Number of individuals 270 103 167
Unadjusted period prevalence (%) 0.07 0.04 0.08
Median age at first event (years) 45.45 45.31 45.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint J10_CHEMGASRESP and mortality.

Females

Parameter HR [95% CI] p-value
J10_CHEMGASRESP 2.547 [1.64, 3.96] < 0.001
Birth year 0.991 [0.98, 1.0] 0.057

During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 394 females with J10_CHEMGASRESP died.

Males

Parameter HR [95% CI] p-value
J10_CHEMGASRESP 2.008 [1.58, 2.55] < 0.001
Birth year 0.992 [0.98, 1.0] 0.069

During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 908 males with J10_CHEMGASRESP died.

Mortality risk

Mortality risk for people of age

years, who have J10_CHEMGASRESP.

N-year risk Females Males
1 0.175% 0.377%
5 1.164% 2.493%
10 3.067% 6.557%
15 6.139% 12.833%
20 10.725% 21.588%

Relationships between endpoints

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Index endpoint: J10_CHEMGASRESP – Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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