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Pneumoconiosis due to other inorganic dusts

DOID EFO Endpoint Browser PheWeb

J10_INORGPNEUMOC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J63
  • Hospital discharge: ICD-9 — 503
  • Hospital discharge: ICD-8 — 51600
  • Cause of death: ICD-10 — J63
  • Cause of death: ICD-9 — 503
  • Cause of death: ICD-8 — 51600

2 out of 7 registries used, show all original rules.

127

4. Check minimum number of events

None

127

5. Include endpoints

None

127

6. Filter based on genotype QC (FinnGen only)

122

Control definitions (FinnGen only)

Control exclude J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J60-J70
Name in latin Pneumoconiosis ex aliis pulveribus inorganicis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1874 796 1036
Only index persons 1034 447 587
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 72.58 76.03 69.86
Only index persons 68.26 72.40 65.11

-FinnGen-

Key figures

All Female Male
Number of individuals 122 35 87
Unadjusted period prevalence (%) 0.04 0.01 0.04
Median age at first event (years) 68.85 65.08 70.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint J10_INORGPNEUMOC and mortality.

Females

Parameter HR [95% CI] p-value
J10_INORGPNEUMOC 2.348 [1.93, 2.85] < 0.001
Birth year 0.996 [0.99, 1.0] 0.312

During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 557 females with J10_INORGPNEUMOC died.

Males

Parameter HR [95% CI] p-value
J10_INORGPNEUMOC 2.514 [2.05, 3.08] < 0.001
Birth year 0.985 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 496 out of 715 males with J10_INORGPNEUMOC died.

Mortality risk

Mortality risk for people of age

years, who have J10_INORGPNEUMOC.

N-year risk Females Males
1 0.211% 0.488%
5 1.365% 2.745%
10 3.496% 6.969%
15 6.78% 12.907%
20 11.869% 21.3%

Relationships between endpoints

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Index endpoint: J10_INORGPNEUMOC – Pneumoconiosis due to other inorganic dusts

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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