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Asthma

DOID Endpoint Browser

J10_ASTHMA

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J45, J46
  • Hospital discharge: ICD-9 — 493
  • Hospital discharge: ICD-8 — 493
  • Cause of death: ICD-10 — J45, J46
  • Cause of death: ICD-9 — 493
  • Cause of death: ICD-8 — 493

2 out of 7 registries used, show all original rules.

54128

4. Check minimum number of events

None

54128

5. Include endpoints

None

54128

6. Filter based on genotype QC (FinnGen only)

52144

Control definitions (FinnGen only)

Control exclude ASTHMA_EXCL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 52144 31985 20159
Unadjusted period prevalence (%) 11.62 12.56 10.12
Median age at first event (years) 48.20 45.59 52.34

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: J10_ASTHMA – Asthma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).