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Asthma (only as main-diagnosis)

Endpoint Browser PheWeb

J10_ASTHMA_MAIN_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Main diagnosis only: side diagnoses are not checked.

Registry filters:

  • Hospital discharge: ICD-10 — J45, J46
  • Hospital discharge: ICD-9 — 493
  • Hospital discharge: ICD-8 — 493
  • Cause of death: ICD-10 — J45, J46
  • Cause of death: ICD-9 — 493
  • Cause of death: ICD-8 — 493

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 459300 236544 220165
Only index persons 391893 207726 184167
Unadjusted period prevalence (%)
Whole population 6.45 6.78 6.15
Only index persons 7.35 7.64 7.03
Median age at first event (years)
Whole population 31.14 41.22 19.99
Only index persons 30.36 39.83 19.68

-FinnGen-

Key figures

All Female Male
Number of individuals 41837 25936 15901
Unadjusted period prevalence (%) 9.35 10.19 7.99
Median age at first event (years) 44.87 42.86 48.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint J10_ASTHMA_MAIN_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
J10_ASTHMA_MAIN_EXMORE 1.381 [1.28, 1.49] < 0.001
Birth year 0.993 [0.99, 1.0] 0.09

During the follow-up period (1.1.1998 — 31.12.2019), 20857 out of 164967 females with J10_ASTHMA_MAIN_EXMORE died.

Males

Parameter HR [95% CI] p-value
J10_ASTHMA_MAIN_EXMORE 1.286 [1.19, 1.39] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 17968 out of 148827 males with J10_ASTHMA_MAIN_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have J10_ASTHMA_MAIN_EXMORE.

N-year risk Females Males
1 0.143% 0.261%
5 0.794% 1.446%
10 1.923% 3.945%
15 3.549% 7.37%
20 6.216% 12.086%

Relationships between endpoints

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Index endpoint: J10_ASTHMA_MAIN_EXMORE – Asthma (only as main-diagnosis)

GWS hits: 53

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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