lung disease: A disease involving the lung.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
65641 |
4. Check minimum number of eventsNone |
65641 |
5. Include endpoints |
83958 |
6. Filter based on genotype QC (FinnGen only) |
81106 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 823800 | 397252 | 418648 |
Only index persons | 667093 | 343513 | 323580 |
Unadjusted period prevalence (%) | |||
Whole population | 11.51 | 11.38 | 11.70 |
Only index persons | 12.49 | 12.63 | 12.35 |
Median age at first event (years) | |||
Whole population | 48.06 | 47.54 | 48.28 |
Only index persons | 43.45 | 45.37 | 41.41 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 81106 | 43834 | 37272 |
Unadjusted period prevalence (%) | 17.91 | 17.22 | 18.72 |
Median age at first event (years) | 50.39 | 44.63 | 57.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_LOWCHRON and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
J10_LOWCHRON | 1.606 [1.48, 1.74] | < 0.001 |
Birth year | 0.992 [0.98, 1.0] | 0.03 |
During the follow-up period (1.1.1998 — 31.12.2019), 38765 out of 249555 females with J10_LOWCHRON died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
J10_LOWCHRON | 2.229 [2.05, 2.42] | < 0.001 |
Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 58577 out of 250657 males with J10_LOWCHRON died.
Mortality risk
Mortality risk for people of age
years, who have J10_LOWCHRON.N-year risk | Females | Males |
---|---|---|
1 | 0.142% | 0.295% |
5 | 0.773% | 1.989% |
10 | 2.059% | 4.777% |
15 | 3.769% | 8.942% |
20 | 6.384% | 14.536% |
Relationships between endpoints
↥Index endpoint: J10_LOWCHRON – Chronic lower respiratory diseases
GWS hits: 72