Chronic lower respiratory diseases

J10_LOWCHRON

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J40-J47
  • Cause of death: ICD-10 J40-J47

2 out of 7 registries used, show all original rules.

65641

4. Check minimum number of events

None

65641

5. Include endpoints

83958

6. Filter based on genotype QC (FinnGen only)

81106

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 823800 397252 418648
Only index persons 667093 343513 323580
Unadjusted period prevalence (%)
Whole population 11.51 11.38 11.70
Only index persons 12.49 12.63 12.35
Median age at first event (years)
Whole population 48.06 47.54 48.28
Only index persons 43.45 45.37 41.41

-FinnGen-

Key figures

All Female Male
Number of individuals 81106 43834 37272
Unadjusted period prevalence (%) 17.91 17.22 18.72
Median age at first event (years) 50.39 44.63 57.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint J10_LOWCHRON and mortality.

Females

Parameter HR [95% CI] p-value
J10_LOWCHRON 1.606 [1.48, 1.74] < 0.001
Birth year 0.992 [0.98, 1.0] 0.03

During the follow-up period (1.1.1998 — 31.12.2019), 38765 out of 249555 females with J10_LOWCHRON died.

Males

Parameter HR [95% CI] p-value
J10_LOWCHRON 2.229 [2.05, 2.42] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 58577 out of 250657 males with J10_LOWCHRON died.

Mortality risk

Mortality risk for people of age

years, who have J10_LOWCHRON.

N-year risk Females Males
1 0.142% 0.295%
5 0.773% 1.989%
10 2.059% 4.777%
15 3.769% 8.942%
20 6.384% 14.536%

Relationships between endpoints

Index endpoint: J10_LOWCHRON – Chronic lower respiratory diseases

GWS hits: 72

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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