Bronchiectasis

J10_BRONCHIECTASIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J47
  • Hospital discharge: ICD-9 494
  • Hospital discharge: ICD-8 51899
  • Cause of death: ICD-10 J47
  • Cause of death: ICD-9 494
  • Cause of death: ICD-8 51899

2 out of 7 registries used, show all original rules.

2686

4. Check minimum number of events

None

2686

5. Include endpoints

None

2686

6. Filter based on genotype QC (FinnGen only)

2597

Control definitions (FinnGen only)

Control exclude J10_LOWCHRON

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J40-J47
Name in latin Bronchiectasia

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19660 10773 8661
Only index persons 15964 9233 6731
Unadjusted period prevalence (%)
Whole population 0.28 0.31 0.24
Only index persons 0.30 0.34 0.26
Median age at first event (years)
Whole population 64.04 63.59 64.67
Only index persons 63.90 63.42 64.55

-FinnGen-

Key figures

All Female Male
Number of individuals 2597 1433 1164
Unadjusted period prevalence (%) 0.57 0.56 0.58
Median age at first event (years) 63.45 62.20 65.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint J10_BRONCHIECTASIS and mortality.

Females

Parameter HR [95% CI] p-value
J10_BRONCHIECTASIS 1.545 [1.4, 1.7] < 0.001
Birth year 0.995 [0.99, 1.0] 0.26

During the follow-up period (1.1.1998 — 31.12.2019), 1891 out of 7086 females with J10_BRONCHIECTASIS died.

Males

Parameter HR [95% CI] p-value
J10_BRONCHIECTASIS 1.732 [1.55, 1.94] < 0.001
Birth year 0.991 [0.98, 1.0] 0.047

During the follow-up period (1.1.1998 — 31.12.2019), 2027 out of 5373 males with J10_BRONCHIECTASIS died.

Mortality risk

Mortality risk for people of age

years, who have J10_BRONCHIECTASIS.

N-year risk Females Males
1 0.149% 0.35%
5 0.891% 2.106%
10 2.296% 5.365%
15 4.16% 9.995%
20 7.387% 17.149%

Relationships between endpoints

Index endpoint: J10_BRONCHIECTASIS – Bronchiectasis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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