COPD

J10_COPD

chronic obstructive pulmonary disease: A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

22310

6. Filter based on genotype QC (FinnGen only)

21617

Control definitions (FinnGen only)

Control exclude J10_LOWCHRON

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 208134 63248 140505
Only index persons 138435 49016 89419
Unadjusted period prevalence (%)
Whole population 3.30 1.81 3.93
Only index persons 2.84 1.80 3.41
Median age at first event (years)
Whole population 67.64 67.35 67.71
Only index persons 66.32 66.13 66.42

-FinnGen-

Key figures

All Female Male
Number of individuals 21617 5695 15922
Unadjusted period prevalence (%) 6.48 2.24 8.00
Median age at first event (years) 67.59 62.79 69.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint J10_COPD and mortality.

Females

Parameter HR [95% CI] p-value
J10_COPD 3.437 [3.14, 3.76] < 0.001
Birth year 0.989 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 20971 out of 45777 females with J10_COPD died.

Males

Parameter HR [95% CI] p-value
J10_COPD 3.108 [2.85, 3.39] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 49010 out of 88208 males with J10_COPD died.

Mortality risk

Mortality risk for people of age

years, who have J10_COPD.

N-year risk Females Males
1 0.3% 0.491%
5 1.68% 2.784%
10 4.223% 6.958%
15 7.44% 12.55%
20 12.769% 20.404%

Relationships between endpoints

Index endpoint: J10_COPD – COPD

GWS hits: 21

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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