pleural empyema: The presence of pus in the thoracic cavity, between the visceral and parietal pleura. [database_cross_reference: NCIT:P378]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2446 |
4. Check minimum number of eventsNone |
2446 |
5. Include endpointsNone |
2446 |
6. Filter based on genotype QC (FinnGen only) |
2377 |
Control definitions (FinnGen only)
Control exclude
J10_LOWCHRON
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J40-J47
Name in latin
Emphysema pulmonale
Similar endpoints
↥List of similar endpoints to
Emphysema
based on the number of shared cases.
Similar with more cases:
- COPD
- Chronic lower respiratory diseases
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
- ILD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 25262 | 6005 | 18635 |
| Only index persons | 14435 | 4338 | 10097 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.44 | 0.17 | 0.52 |
| Only index persons | 0.32 | 0.16 | 0.39 |
| Median age at first event (years) | |||
| Whole population | 68.18 | 67.77 | 68.36 |
| Only index persons | 67.82 | 66.92 | 68.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2377 | 604 | 1773 |
| Unadjusted period prevalence (%) | 0.72 | 0.24 | 0.89 |
| Median age at first event (years) | 69.21 | 65.67 | 70.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_EMPHYSEMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_EMPHYSEMA | 3.684 [3.14, 4.33] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 1167 out of 3260 females with J10_EMPHYSEMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_EMPHYSEMA | 3.237 [2.81, 3.72] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 3606 out of 7590 males with J10_EMPHYSEMA died.
Mortality risk
Mortality risk for people of age
years, who have J10_EMPHYSEMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.307% | 0.643% |
| 5 | 1.856% | 3.69% |
| 10 | 4.444% | 8.79% |
| 15 | 8.028% | 16.011% |
| 20 | 13.584% | 25.898% |
Relationships between endpoints
↥Index endpoint: J10_EMPHYSEMA – Emphysema
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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