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Bronchitis, not specified as acute or chronic

DOID EFO Endpoint Browser PheWeb

J10_BRONCH

bronchitis: An acute or chronic inflammatory process affecting the bronchi. [database_cross_reference: NCIT:C2911]

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J40
  • Hospital discharge: ICD-9 — 490
  • Hospital discharge: ICD-8 — 49099
  • Cause of death: ICD-10 — J40
  • Cause of death: ICD-9 — 490
  • Cause of death: ICD-8 — 49099

2 out of 7 registries used, show all original rules.

3479

4. Check minimum number of events

None

3479

5. Include endpoints

None

3479

6. Filter based on genotype QC (FinnGen only)

3366

Control definitions (FinnGen only)

Control exclude J10_LOWCHRON

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J40-J47
Name in latin Bronchitis non specificata utrum acuta an chronica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 45745 19996 25104
Only index persons 31269 13713 17556
Unadjusted period prevalence (%)
Whole population 0.64 0.57 0.70
Only index persons 0.60 0.50 0.67
Median age at first event (years)
Whole population 42.04 52.72 33.02
Only index persons 30.35 43.02 20.46

-FinnGen-

Key figures

All Female Male
Number of individuals 3366 1489 1877
Unadjusted period prevalence (%) 0.78 0.58 0.94
Median age at first event (years) 32.53 38.50 27.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint J10_BRONCH and mortality.

Females

Parameter HR [95% CI] p-value
J10_BRONCH 1.698 [1.51, 1.91] < 0.001
Birth year 0.996 [0.99, 1.0] 0.384

During the follow-up period (1.1.1998 — 31.12.2019), 1909 out of 5827 females with J10_BRONCH died.

Males

Parameter HR [95% CI] p-value
J10_BRONCH 2.105 [1.81, 2.44] < 0.001
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 1998 out of 5250 males with J10_BRONCH died.

Mortality risk

Mortality risk for people of age

years, who have J10_BRONCH.

N-year risk Females Males
1 0.114% 0.399%
5 1.039% 2.452%
10 2.624% 6.119%
15 5.02% 11.305%
20 8.786% 18.783%

Relationships between endpoints

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Index endpoint: J10_BRONCH – Bronchitis, not specified as acute or chronic

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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