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Simple and mucopurulent chronic bronchitis

DOID EFO Endpoint Browser PheWeb

J10_SIMPLBRONCH

bronchitis: An acute or chronic inflammatory process affecting the bronchi. [database_cross_reference: NCIT:C2911]

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J41
  • Hospital discharge: ICD-9 — 491[0-1]
  • Hospital discharge: ICD-8 — 4910[1-2]
  • Cause of death: ICD-10 — J41
  • Cause of death: ICD-9 — 491[0-1]
  • Cause of death: ICD-8 — 4910[1-2]

2 out of 7 registries used, show all original rules.

1623

4. Check minimum number of events

None

1623

5. Include endpoints

None

1623

6. Filter based on genotype QC (FinnGen only)

1549

Control definitions (FinnGen only)

Control exclude J10_LOWCHRON

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J40-J47
Name in latin Bronchitis chronica simplex sive mucopurulenta

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19612 7277 11777
Only index persons 9480 4605 4875
Unadjusted period prevalence (%)
Whole population 0.29 0.21 0.33
Only index persons 0.18 0.17 0.19
Median age at first event (years)
Whole population 59.51 57.01 60.88
Only index persons 52.89 52.77 53.00

-FinnGen-

Key figures

All Female Male
Number of individuals 1549 580 969
Unadjusted period prevalence (%) 0.39 0.23 0.49
Median age at first event (years) 54.54 49.00 57.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint J10_SIMPLBRONCH and mortality.

Females

Parameter HR [95% CI] p-value
J10_SIMPLBRONCH 2.004 [1.78, 2.25] < 0.001
Birth year 0.993 [0.98, 1.0] 0.111

During the follow-up period (1.1.1998 — 31.12.2019), 1102 out of 3129 females with J10_SIMPLBRONCH died.

Males

Parameter HR [95% CI] p-value
J10_SIMPLBRONCH 2.066 [1.84, 2.32] < 0.001
Birth year 0.989 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 1687 out of 3566 males with J10_SIMPLBRONCH died.

Mortality risk

Mortality risk for people of age

years, who have J10_SIMPLBRONCH.

N-year risk Females Males
1 0.186% 0.437%
5 1.027% 2.415%
10 2.692% 5.921%
15 5.329% 11.176%
20 9.318% 18.593%

Relationships between endpoints

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Index endpoint: J10_SIMPLBRONCH – Simple and mucopurulent chronic bronchitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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