No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
ALLERG_ASTHMA, VOCALCORDDYS, I9_HEARTFAIL, J10_HYPERSPNEUMONI, ASTHMA_EXCL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Asthma
based on the number of shared cases.
Similar with more cases:
- Asthma
- Asthma, including avohilmo
- Chronic lower respiratory diseases
- COPD differential diagnosis
- ILD differential diagnosis
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 549294 | 287748 | 258223 |
| Only index persons | 469528 | 253690 | 215838 |
| Unadjusted period prevalence (%) | |||
| Whole population | 7.73 | 8.24 | 7.21 |
| Only index persons | 8.83 | 9.33 | 8.24 |
| Median age at first event (years) | |||
| Whole population | 37.27 | 45.52 | 27.78 |
| Only index persons | 35.48 | 44.12 | 25.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 52144 | 31985 | 20159 |
| Unadjusted period prevalence (%) | 11.62 | 12.56 | 10.12 |
| Median age at first event (years) | 48.20 | 45.59 | 52.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_ASTHMA_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASTHMA_EXMORE | 1.416 [1.3, 1.54] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.312 |
During the follow-up period (1.1.1998 — 31.12.2019), 29528 out of 202051 females with J10_ASTHMA_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASTHMA_EXMORE | 1.539 [1.41, 1.68] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 25664 out of 174587 males with J10_ASTHMA_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have J10_ASTHMA_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | 0.221% |
| 5 | 0.799% | 1.393% |
| 10 | 2.004% | 3.478% |
| 15 | 3.851% | 6.738% |
| 20 | 6.738% | 11.48% |
Relationships between endpoints
↥Index endpoint: J10_ASTHMA_EXMORE – Asthma
GWS hits: 61
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data