asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersCheck mode of ICD-10 codes: %J450 Registry filters: 2 out of 7 registries used, show all original rules. |
12344 |
4. Check minimum number of eventsNone |
12344 |
5. Include endpointsNone |
12344 |
6. Filter based on genotype QC (FinnGen only) |
11867 |
Control definitions (FinnGen only)
Control exclude
J10_ASTHMA, ASTHMA_EXCL
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Allergic asthma (mode)
based on the number of shared cases.
Similar with more cases:
- Allergic asthma (mode)
- Asthma (diagnoses ohter than nonallergic)
- Asthma
- Asthma
- Asthma, including avohilmo
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 133656 | 66566 | 66695 |
| Only index persons | 122676 | 62228 | 60448 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.88 | 1.91 | 1.86 |
| Only index persons | 2.30 | 2.29 | 2.31 |
| Median age at first event (years) | |||
| Whole population | 21.04 | 29.00 | 12.92 |
| Only index persons | 21.66 | 29.46 | 13.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 11867 | 7803 | 4064 |
| Unadjusted period prevalence (%) | 2.71 | 3.06 | 2.04 |
| Median age at first event (years) | 36.91 | 36.19 | 38.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ALLERG_ASTHMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ALLERG_ASTHMA | 1.495 [1.36, 1.64] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.137 |
During the follow-up period (1.1.1998 — 31.12.2019), 4709 out of 60557 females with ALLERG_ASTHMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ALLERG_ASTHMA | 1.353 [1.23, 1.48] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 4063 out of 60591 males with ALLERG_ASTHMA died.
Mortality risk
Mortality risk for people of age
years, who have ALLERG_ASTHMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.102% | 0.228% |
| 5 | 0.732% | 1.548% |
| 10 | 2.062% | 4.222% |
| 15 | 4.002% | 8.155% |
| 20 | 6.972% | 13.882% |
Relationships between endpoints
↥Index endpoint: ALLERG_ASTHMA – Allergic asthma (mode)
GWS hits: 28
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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