No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
53726 |
4. Check minimum number of eventsNone |
53726 |
5. Include endpointsNone |
53726 |
6. Filter based on genotype QC (FinnGen only) |
52013 |
Control definitions (FinnGen only)
Control exclude
J10_LOWCHRON
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Asthma/COPD (KELA code 203)
based on the number of shared cases.
Similar with more cases:
- Chronic lower respiratory diseases
- Diseases of the respiratory system
- Any reimbursement code in KELA
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 412000 | 226125 | 182179 |
| Only index persons | 342686 | 199568 | 143118 |
| Unadjusted period prevalence (%) | |||
| Whole population | 5.84 | 6.48 | 5.09 |
| Only index persons | 6.55 | 7.34 | 5.46 |
| Median age at first event (years) | |||
| Whole population | 51.19 | 49.76 | 52.75 |
| Only index persons | 49.00 | 48.35 | 49.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 52013 | 30392 | 21621 |
| Unadjusted period prevalence (%) | 11.49 | 11.94 | 10.86 |
| Median age at first event (years) | 48.34 | 43.99 | 54.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_ASTHMACOPDKELA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASTHMACOPDKELA | 1.407 [1.3, 1.52] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 17921 out of 132821 females with J10_ASTHMACOPDKELA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASTHMACOPDKELA | 1.6 [1.48, 1.73] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 25412 out of 107658 males with J10_ASTHMACOPDKELA died.
Mortality risk
Mortality risk for people of age
years, who have J10_ASTHMACOPDKELA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.125% | 0.26% |
| 5 | 0.688% | 1.682% |
| 10 | 1.746% | 4.055% |
| 15 | 3.257% | 7.551% |
| 20 | 5.611% | 13.213% |
Relationships between endpoints
↥Index endpoint: J10_ASTHMACOPDKELA – Asthma/COPD (KELA code 203)
GWS hits: 92
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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