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Non-allergic asthma

ASTHMA_NONALLERG

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • not (J10_ASTHMA_OTHER_THAN_NONALLERGIC
  • or L12_ATOPIC
  • or ALLERG_RHINITIS
  • or H7_ALLERGICCONJUNCTIVITIS
  • or FOOD_ALLERGY
  • or Z21_DESEN_ALLERGE
  • or POLLENALLERG
382930

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

3326

6. Filter based on genotype QC (FinnGen only)

3163

Control definitions (FinnGen only)

Control conditions not (L12_ATOPIC
or ALLERG_RHINITIS
or H7_ALLERGICCONJUNCTIVITIS
or FOOD_ALLERGY
or Z21_DESEN_ALLERGE
or POLLENALLERG

Extra metadata

First used in FinnGen datafreeze DF9

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 3163 1764 1399
Unadjusted period prevalence (%) 0.70 0.69 0.70
Median age at first event (years) 55.52 53.05 58.62

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ASTHMA_NONALLERG – Non-allergic asthma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).