No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
43940 |
4. Check minimum number of eventsNone |
43940 |
5. Include endpoints |
49145 |
6. Filter based on genotype QC (FinnGen only) |
47199 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 535107 | 324247 | 206308 |
Only index persons | 427654 | 259741 | 167913 |
Unadjusted period prevalence (%) | |||
Whole population | 7.89 | 9.29 | 5.76 |
Only index persons | 8.32 | 9.55 | 6.41 |
Median age at first event (years) | |||
Whole population | 68.15 | 66.74 | 70.32 |
Only index persons | 66.33 | 64.14 | 69.71 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 47199 | 25309 | 21890 |
Unadjusted period prevalence (%) | 10.43 | 9.94 | 10.99 |
Median age at first event (years) | 62.12 | 55.03 | 70.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_RENALTUB and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
N14_RENALTUB | 2.848 [2.6, 3.12] | < 0.001 |
Birth year | 0.986 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 81588 out of 200930 females with N14_RENALTUB died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
N14_RENALTUB | 3.132 [2.8, 3.5] | < 0.001 |
Birth year | 0.98 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 67072 out of 143531 males with N14_RENALTUB died.
Mortality risk
Mortality risk for people of age
years, who have N14_RENALTUB.N-year risk | Females | Males |
---|---|---|
1 | 0.209% | 0.33% |
5 | 1.034% | 2.328% |
10 | 2.534% | 5.454% |
15 | 4.59% | 10.191% |
20 | 7.953% | 16.258% |
Relationships between endpoints
↥Index endpoint: N14_RENALTUB – Renal tubulo-interstitial diseases
GWS hits: 2