Renal tubulo-interstitial diseases

N14_RENALTUB

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

43940

4. Check minimum number of events

None

43940

5. Include endpoints

49145

6. Filter based on genotype QC (FinnGen only)

47199

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 535107 324247 206308
Only index persons 427654 259741 167913
Unadjusted period prevalence (%)
Whole population 7.89 9.29 5.76
Only index persons 8.32 9.55 6.41
Median age at first event (years)
Whole population 68.15 66.74 70.32
Only index persons 66.33 64.14 69.71

-FinnGen-

Key figures

All Female Male
Number of individuals 47199 25309 21890
Unadjusted period prevalence (%) 10.43 9.94 10.99
Median age at first event (years) 62.12 55.03 70.33

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint N14_RENALTUB and mortality.

Females

Parameter HR [95% CI] p-value
N14_RENALTUB 2.848 [2.6, 3.12] < 0.001
Birth year 0.986 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 81588 out of 200930 females with N14_RENALTUB died.

Males

Parameter HR [95% CI] p-value
N14_RENALTUB 3.132 [2.8, 3.5] < 0.001
Birth year 0.98 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 67072 out of 143531 males with N14_RENALTUB died.

Mortality risk

Mortality risk for people of age

years, who have N14_RENALTUB.

N-year risk Females Males
1 0.209% 0.33%
5 1.034% 2.328%
10 2.534% 5.454%
15 4.59% 10.191%
20 7.953% 16.258%

Relationships between endpoints

Index endpoint: N14_RENALTUB – Renal tubulo-interstitial diseases

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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