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Chronic tubulo-interstitial nephritis

DOID EFO Endpoint Browser PheWeb

N14_CHRONTUBULOINTNEPHRITIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N11
  • Hospital discharge: ICD-9 — 5900
  • Hospital discharge: ICD-8 — 5900
  • Cause of death: ICD-10 — N11
  • Cause of death: ICD-9 — 5900
  • Cause of death: ICD-8 — 5900

2 out of 7 registries used, show all original rules.

1407

4. Check minimum number of events

None

1407

5. Include endpoints

None

1407

6. Filter based on genotype QC (FinnGen only)

1362

Control definitions (FinnGen only)

Control exclude N14_RENALTUB

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N10-N16
Name in latin Nephritis tubulo-interstitialis chronica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 23871 18322 5172
Only index persons 11082 8554 2528
Unadjusted period prevalence (%)
Whole population 0.44 0.52 0.14
Only index persons 0.26 0.31 0.10
Median age at first event (years)
Whole population 60.92 59.62 65.52
Only index persons 38.86 33.94 55.52

-FinnGen-

Key figures

All Female Male
Number of individuals 1362 988 374
Unadjusted period prevalence (%) 0.33 0.39 0.19
Median age at first event (years) 37.38 29.86 57.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_CHRONTUBULOINTNEPHRITIS and mortality.

Females

Parameter HR [95% CI] p-value
N14_CHRONTUBULOINTNEPHRITIS 2.441 [2.1, 2.84] < 0.001
Birth year 0.995 [0.99, 1.0] 0.254

During the follow-up period (1.1.1998 — 31.12.2019), 1294 out of 2663 females with N14_CHRONTUBULOINTNEPHRITIS died.

Males

Parameter HR [95% CI] p-value
N14_CHRONTUBULOINTNEPHRITIS 2.642 [2.17, 3.22] < 0.001
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 951 out of 1926 males with N14_CHRONTUBULOINTNEPHRITIS died.

Mortality risk

Mortality risk for people of age

years, who have N14_CHRONTUBULOINTNEPHRITIS.

N-year risk Females Males
1 0.242% 0.371%
5 1.582% 2.644%
10 3.572% 6.84%
15 6.468% 12.857%
20 11.639% 21.301%

Relationships between endpoints

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Index endpoint: N14_CHRONTUBULOINTNEPHRITIS – Chronic tubulo-interstitial nephritis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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