No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
30721 |
4. Check minimum number of eventsNone |
30721 |
5. Include endpointsNone |
30721 |
6. Filter based on genotype QC (FinnGen only) |
29521 |
Control definitions (FinnGen only)
Control exclude
N14_RENALTUB
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N10-N16
Name in latin
Nephritis tubulo-interstitialis acuta
Acute tubulo-interstitial nephritis
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 357461 | 241013 | 113711 |
| Only index persons | 286822 | 194611 | 92211 |
| Unadjusted period prevalence (%) | |||
| Whole population | 5.69 | 6.90 | 3.18 |
| Only index persons | 5.99 | 7.15 | 3.52 |
| Median age at first event (years) | |||
| Whole population | 66.24 | 64.40 | 70.10 |
| Only index persons | 63.65 | 60.89 | 69.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 29521 | 18357 | 11164 |
| Unadjusted period prevalence (%) | 6.60 | 7.21 | 5.61 |
| Median age at first event (years) | 59.08 | 52.08 | 70.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_PYELONEPHR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_PYELONEPHR | 2.358 [2.14, 2.6] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 59088 out of 154909 females with N14_PYELONEPHR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_PYELONEPHR | 2.465 [2.19, 2.77] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 35641 out of 80778 males with N14_PYELONEPHR died.
Mortality risk
Mortality risk for people of age
years, who have N14_PYELONEPHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.165% | 0.374% |
| 5 | 1.119% | 2.321% |
| 10 | 2.551% | 5.742% |
| 15 | 4.663% | 10.466% |
| 20 | 8.16% | 17.159% |
Relationships between endpoints
↥Index endpoint: N14_PYELONEPHR – Acute tubulo-interstitial nephritis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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