kidney disease: A disease involving the kidney.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
841 |
4. Check minimum number of eventsNone |
841 |
5. Include endpointsNone |
841 |
6. Filter based on genotype QC (FinnGen only) |
801 |
Control definitions (FinnGen only)
Control exclude
N14_RENALTUB
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N10-N16
Name in latin
Aliae nephropathiae tubulo-interstitiales
Similar endpoints
↥List of similar endpoints to
Other renal tubulo-interstitial diseases
based on the number of shared cases.
Similar with more cases:
- Renal tubulo-interstitial diseases
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9679 | 7187 | 2383 |
| Only index persons | 6588 | 5004 | 1584 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.21 | 0.07 |
| Only index persons | 0.15 | 0.18 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 38.03 | 34.69 | 47.32 |
| Only index persons | 22.72 | 20.14 | 30.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 801 | 612 | 189 |
| Unadjusted period prevalence (%) | 0.21 | 0.24 | 0.09 |
| Median age at first event (years) | 26.89 | 19.93 | 49.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint N14_RENALTUBULOOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RENALTUBULOOTH | 2.213 [1.69, 2.9] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.631 |
During the follow-up period (1.1.1998 — 31.12.2019), 243 out of 782 females with N14_RENALTUBULOOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RENALTUBULOOTH | 2.768 [2.02, 3.79] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 196 out of 576 males with N14_RENALTUBULOOTH died.
Mortality risk
Mortality risk for people of age
years, who have N14_RENALTUBULOOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.2% | 0.509% |
| 5 | 1.23% | 3.245% |
| 10 | 3.341% | 7.871% |
| 15 | 6.65% | 14.263% |
| 20 | 11.615% | 22.939% |
Relationships between endpoints
↥Index endpoint: N14_RENALTUBULOOTH – Other renal tubulo-interstitial diseases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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