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Other obstructive and reflux uropathy

DOID EFO Endpoint Browser PheWeb

N14_OBSTRUREFLUROPATH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N13
  • Hospital discharge: ICD-9 — 5933|5934|5935|5937
  • Hospital discharge: ICD-8 — 5933|5934|5935
  • Hospital discharge: excluded ICD-9 — N13[0-3]
  • Cause of death: ICD-10 — N13
  • Cause of death: ICD-9 — 5933|5934|5935|5937
  • Cause of death: ICD-8 — 5933|5934|5935
  • Cause of death: excluded ICD-9 — N13[0-3]

2 out of 7 registries used, show all original rules.

4921

4. Check minimum number of events

None

4921

5. Include endpoints

None

4921

6. Filter based on genotype QC (FinnGen only)

4705

Control definitions (FinnGen only)

Control exclude N14_RENALTUB

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N10-N16
Name in latin Uropathia ex obstructione sive refluxu

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 44368 22397 21604
Only index persons 38039 19821 18218
Unadjusted period prevalence (%)
Whole population 0.62 0.64 0.60
Only index persons 0.71 0.73 0.70
Median age at first event (years)
Whole population 58.77 51.89 65.78
Only index persons 56.13 47.94 65.04

-FinnGen-

Key figures

All Female Male
Number of individuals 4705 2403 2302
Unadjusted period prevalence (%) 1.05 0.94 1.16
Median age at first event (years) 59.51 50.59 68.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_OBSTRUREFLUROPATH and mortality.

Females

Parameter HR [95% CI] p-value
N14_OBSTRUREFLUROPATH 3.569 [3.18, 4.0] < 0.001
Birth year 0.994 [0.99, 1.0] 0.12

During the follow-up period (1.1.1998 — 31.12.2019), 5115 out of 14736 females with N14_OBSTRUREFLUROPATH died.

Males

Parameter HR [95% CI] p-value
N14_OBSTRUREFLUROPATH 2.792 [2.46, 3.17] < 0.001
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 6712 out of 15515 males with N14_OBSTRUREFLUROPATH died.

Mortality risk

Mortality risk for people of age

years, who have N14_OBSTRUREFLUROPATH.

N-year risk Females Males
1 0.246% 0.478%
5 1.96% 3.205%
10 4.824% 7.98%
15 9.207% 14.529%
20 15.533% 23.713%

Relationships between endpoints

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Index endpoint: N14_OBSTRUREFLUROPATH – Other obstructive and reflux uropathy

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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