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Tubulo-interstitial nephritis, not specified as acute or chronic

DOID EFO Endpoint Browser PheWeb

N14_TUBULOINTNEPHRNAS

pyelonephritis: Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N12
  • Hospital discharge: ICD-9 — 5909
  • Hospital discharge: ICD-8 — 5909
  • Cause of death: ICD-10 — N12
  • Cause of death: ICD-9 — 5909
  • Cause of death: ICD-8 — 5909

2 out of 7 registries used, show all original rules.

2680

4. Check minimum number of events

None

2680

5. Include endpoints

None

2680

6. Filter based on genotype QC (FinnGen only)

2568

Control definitions (FinnGen only)

Control exclude N14_RENALTUB

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N10-N16
Name in latin Nephritis tubulo-interstitialis sine specificatione utrum acuta an chronica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 33191 21919 11009
Only index persons 27247 18160 9087
Unadjusted period prevalence (%)
Whole population 0.52 0.63 0.31
Only index persons 0.56 0.67 0.35
Median age at first event (years)
Whole population 68.81 67.71 70.98
Only index persons 67.30 65.80 70.28

-FinnGen-

Key figures

All Female Male
Number of individuals 2568 1594 974
Unadjusted period prevalence (%) 0.57 0.63 0.49
Median age at first event (years) 56.68 48.59 69.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_TUBULOINTNEPHRNAS and mortality.

Females

Parameter HR [95% CI] p-value
N14_TUBULOINTNEPHRNAS 2.393 [2.11, 2.71] < 0.001
Birth year 0.994 [0.99, 1.0] 0.126

During the follow-up period (1.1.1998 — 31.12.2019), 6559 out of 13875 females with N14_TUBULOINTNEPHRNAS died.

Males

Parameter HR [95% CI] p-value
N14_TUBULOINTNEPHRNAS 2.579 [2.22, 3.0] < 0.001
Birth year 0.989 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 4318 out of 8081 males with N14_TUBULOINTNEPHRNAS died.

Mortality risk

Mortality risk for people of age

years, who have N14_TUBULOINTNEPHRNAS.

N-year risk Females Males
1 0.191% 0.453%
5 1.186% 2.861%
10 3.107% 7.734%
15 6.123% 14.366%
20 10.785% 24.075%

Relationships between endpoints

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Index endpoint: N14_TUBULOINTNEPHRNAS – Tubulo-interstitial nephritis, not specified as acute or chronic

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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