kidney failure: An acute or chronic condition that is characterized by the inability of the kidneys to adequately filter the blood. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3436 |
4. Check minimum number of eventsNone |
3436 |
5. Include endpointsNone |
3436 |
6. Filter based on genotype QC (FinnGen only) |
3278 |
Control definitions (FinnGen only)
Control exclude
N14_RENFAIL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N17-N19
Name in latin
Insufficientia renalis non specificata
Similar endpoints
↥List of similar endpoints to
Unspecified kidney failure
based on the number of shared cases.
Similar with more cases:
- Renal failure
- Renal tubulo-interstitial diseases
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 34545 | 15967 | 18282 |
| Only index persons | 29564 | 13860 | 15704 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.48 | 0.46 | 0.51 |
| Only index persons | 0.56 | 0.51 | 0.60 |
| Median age at first event (years) | |||
| Whole population | 78.80 | 81.83 | 76.21 |
| Only index persons | 78.80 | 81.97 | 76.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3278 | 1144 | 2134 |
| Unadjusted period prevalence (%) | 0.85 | 0.45 | 1.07 |
| Median age at first event (years) | 73.95 | 73.42 | 74.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_RENFAILNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RENFAILNAS | 3.666 [3.09, 4.35] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.058 |
During the follow-up period (1.1.1998 — 31.12.2019), 6647 out of 10889 females with N14_RENFAILNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RENFAILNAS | 3.836 [3.15, 4.67] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 7386 out of 12604 males with N14_RENFAILNAS died.
Mortality risk
Mortality risk for people of age
years, who have N14_RENFAILNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.368% | 0.538% |
| 5 | 1.865% | 3.499% |
| 10 | 4.868% | 9.075% |
| 15 | 8.795% | 16.959% |
| 20 | 15.067% | 27.94% |
Relationships between endpoints
↥Index endpoint: N14_RENFAILNAS – Unspecified kidney failure
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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